UPDATE 2-Takeda joins effort to develop Zika vaccine with U.S. funding
(Adds Florida traps first mosquitoes to test positive for Zika in U.S.)
By Bill Berkrot
Sept 1 (Reuters) - Japanese drugmaker Takeda Pharmaceutical Co on Thursday said it is developing a vaccine to prevent the Zika virus, which has been linked to severe birth defects, and has secured funding from a U.S. government agency.
Takeda, which is also working on vaccines for other mosquito-borne viruses such as dengue, said it would initially receive nearly $20 million over the next 18 months to fund pre-clinical research and manufacturing in preparation for early human trials.
The contract is with BARDA, the U.S. Biomedical Advanced Research and Development Authority, a unit within the U.S. Department of Health and Human Services. It calls for funding of up to $312 million if the agency deems the vaccine worthy of moving through late stage testing and filing for approval, the company said.
Takeda has been conducting preclinical testing for several months and hopes to begin Phase I trials in healthy volunteers in the second half of 2017, Rajeev Venkayya, head of global vaccines for Takeda, said in a telephone interview.
The company said it was also in discussions with the Japanese government on its possible participation in the Zika collaboration.
The Takeda vaccine will utilize inactivated, or killed, whole Zika virus to promote an immune response, Venkayya said. The vaccines now in early human testing are DNA-based and contain no actual virus.
"To help protect people from Zika in the U.S. and abroad, we are aggressively pursuing the development of promising vaccine candidates around the world," Richard Hatchett, acting director of BARDA said in a statement. Continuación...